Genetic variation in Aldo - keto reductase 1 D 1 ( AKR 1 D 1 ) affects the expression and activity of multiple Cytochrome P 450 s ( CYPs )
نویسندگان
چکیده
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, (A.S.C., R.K.T., K.Y., E.G.S.), Department of Computational Biology, St Jude Children’s Research Hospital, Memphis, TN (Y.F.), Department of Integrative Biology and Physiology, University of California, Los Angeles, CA (X.Y.), Department of Laboratory Medicine, Division of Pathology, Karolinska Instituet, Stockholm, Sweden (S.C.S.). DMD Fast Forward. Published on May 23, 2013 as doi:10.1124/dmd.113.051672
منابع مشابه
Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.
Human liver gene regulatory (Bayesian) network analysis was previously used to identify a cytochrome P450 (P450) gene subnetwork with Aldo-keto reductase 1D1 (AKR1D1) as a key regulatory driver of this subnetwork. This study assessed the biologic importance of AKR1D1 [a key enzyme in the synthesis of bile acids, ligand activators of farnesoid X receptor (FXR), pregnane X receptor (PXR), and con...
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Aldo-keto reductase family 1 B10 (AKR1B10) is a member of the NADPH-dependent aldo-keto reductase (AKR) superfamily, and has been considered to be a potential cancer therapeutic target. Total extract from the bark of Rhus verniciflua (Toxicodendron vernicifluum (Stokes)) showed AKR1B10 inhibitory activity. To identify the active compounds from R. verniciflua responsible for AKR1B10 inhibition, ...
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Cyclopentenone prostaglandins (cyPG) are reactive eicosanoids that may display anti-inflammatory and antiproliferative actions, possibly offering therapeutic potential. Here we report the identification of members of the aldo-keto reductase (AKR) family as selective targets of the cyPG prostaglandin A(1) (PGA(1)). AKR enzymes metabolize aldehydes and drugs containing carbonyl groups and are inv...
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